Khand was the realm located southeast of Mordor; as a result, it was likely always strongly influenced by Sauron. The Men of Khand, known as Variags, fought in Sauron’s army and even supplied Mordor with horses. Little else is known about the land or the peoples who inhabited it, though it is likely that they were similar in nature to Rohan, in that horses and riding played an important role in their culture.
In TA 1944, the Variags joined the Wainriders in attacking Gondor, and during the War of the Ring they took part in the Battle of the Pelennor Fields. They were eventually driven back by the Knights of Dol Amroth, and the land likely fell under the control of Gondor by the Fourth Age, thus quenching their hostilities.